Recently, Dr. Anna Porwit, Hematopathologist, Laboratory Medicine Program (LMP) had her work on mixed-phenotype acute leukemia (MPAL) published in the American Journal for Clinical Pathology. The study is part of a workshop series by the Society for Hematopathology/European Association for Haematopathology and summarizes diagnostic criteria for major types of MPAL.
There were 32 cases included in this session of the workshop, and the publication illustrates and describes the variability of MPAL, the technical issues involved in diagnosis, and how cases can be linked by common characteristics.
More detailed, the study discusses: technical issues in determining blast lineage, possible pitfalls in MPAL diagnosis, and the differential diagnosis between acute undifferentiated leukemia and acute myeloid leukemia with minimal differentiation.
The study emphasizes the need for: flow cytometry immunophenotyping using a large panel of antibodies, as well as confirmatory immunohistochemical analysis and cytochemistry studies to accurately establish the diagnosis of MPAL.
For more information see: HERE